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. Author manuscript; available in PMC: 2010 Dec 14.
Published in final edited form as: J Immunol. 2009 Dec 15;183(12):8244. doi: 10.4049/jimmunol.0901958

FIGURE 4.

FIGURE 4

Both inflammation and fibrosis are diminished in zIETD-fmk-treated reovirus 1/L-induced ARDS or BOOP. CBA/J mice were i.n. inoculated with either 1 × 106 PFU (BOOP) or 1 × 107 PFU (ARDS) reovirus 1/L and were left untreated or treated with 5 mg/kg of either zVAD-fmk or zIETD-fmk daily beginning on day 3 postinoculation. A, Reovirus 1/L-induced ARDS at day 9 (H&E). B, Reovirus 1/L-induced ARDS at day 14 (Masson's trichrome). C, Reovirus 1/L-induced BOOP at day 21 (H&E). Objective magnification, ×20. Results are representative of four independent experiments evaluating four mice per time point.