Table 1.
Growth advantages in the liaS mutant
| Mode of Action | Compounds |
|---|---|
| Cell wall synthesis | Fosphomycin, Glycine, Cefsulodin, Cetoperazone, cephalosporin, Cefoxitin, Moxalactam, Piperacillin, D-Cycloserine, Ceftriaxone |
| Membrane and ion channel | 4-Aminopyridine, Polymyxin B, Colistin |
| DNA damage | Semicarbazide hydrochloride, Hydroxylamine, Phleomycin |
| DNA synthesis | Nitrofurantoin, Bleomycin |
| DNA unwinding | Norfloxacin, Ciprofloxacin, Oxolinic acid, Lomefloxacin, Ofloxacin, Enoxacin, Nalidixic acid |
| DNA intercalator | 4-Hydroxycoumarin |
| DNA methyltransferase | 5-Azacytidine |
| Nucleic acid analogs | Cytosine arabinoside, 5-Fluorouracil, 5-Fluoro-5′-deoxyuridine |
| Folate antagonist | Sulfachloropyridazine, Sulfanilamide, Sulfamethazine, Sulfamethoxazole, Trimethoprim,, Sulfisoxazole |
| Ribonucletide reductase | Hydroxyurea |
| Thymidylate synthetase | Trifluorothymidine |
| t-RNA synthetase | L-Glutamic-g-Hydroxamate, Glycine Hydroxamate |
| Protein synthesis | Cinoxacin, Capreomycin, Chloramphenicol, Spectinomycin*, Streptomycin, Hygromycin, Geneticin (G418), Tetracycline, Gentamicin, Amikacin, Kanamycin, Minocycline |
| Osmotic sensitivity | 1% NaCl, 3% Sodium Sulfate |
| Oxidizing agents | D,L-ThiocticAcid |
| Respiration | Pentachlorophenol (PCP), Sorbic Acid, Sodium Caprylate, Cinnamic Acid, Sodium azide |
| Toxic anion | Sodium Nitrite, Sodium Metaborate, Sodium Tungstate, Sodium Arsenate, Sodium Dichromate |
| Toxic cation | Cesium chloride, Thallium (I) acetate, Chromium Chloride, Ferric Chloride, Aluminum Sulfate, Boric Acid, Potassium Tellurite, Sodium periodate, Potassium chromate, Sodium metasilicate |
| Chelating agents | Sodium pyrophosphate decahydrate, EGTA, EDTA, Fusaric Acid |
| Others* | 5-Fluoroorotic Acid, Chlorambucil, Thiosalicylate, Ethionamide, Patulin, Apramycin, Triclosan, Chloroxylenol, Aminotriazole, PMSF, Phenylarsine Oxide |
a
Mode of action includes anti-capsule, antimicrobial, fatty-acid synthesis, histidine biosynthesis, tyrosine phosphatase.
*
IBS148 contains a spectinomycin resistant gene.