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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Cancer Lett. 2008 Mar 7;262(2):153. doi: 10.1016/j.canlet.2008.01.033

Table 2.

Chemo-/radio-sensitizing effects of indole-3-carbinol and DIM

Treatment Cell model Proposed mechanism (ref)
Indole-3-carbinol
Cisplatin Cervical cancer cells Downregulation of Bcl-2 expression (99)
LNCaP prostate cancer cells Inhibition of Akt/NF-κB signaling (20)
Tamoxifen MCF-7 breast cancer cells Downregulation of CDK6 expression (82)
TRAIL LNCaP cells (TRAIL-resistant) Induction of death receptor (DR)4 and DR5 expression (88)
Ultraviolet B Melanoma cells Downregulation of Bcl-2 expression (100)
DIM
Taxotere MDA-MB-231 breast cancer cells Inactivation of Akt/NF-κB signaling (45)
Paclitaxel Her2/Neu breast cancer cells Downregulation of Bcl-2 expression and Her2/Neu activation (101)