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Modification of the hexon reduces infection of hepatocytes with oncolytic Ad. (a) ICR mice were injected i.v. with 3 × 1010 vp of Ad-GL or Ad-GL-HB. Some mice were pretreated with warfarin. Luciferase expression in the liver was detected by whole-body imaging on day 1 after virus injection. (b) Quantification of the luminescence signal from a. Ad, adenovirus; ICR, Imperial Cancer Research; i.v., intravenous; vp, virus particles.
