Table 1.
Reported differences in overall survival based on margin status (R0 vs. R1 resection) after hepatic resection for colorectal liver metastases
| Author(s) | Year | n | Study period | Follow-up, months | R1 rate |
Survival |
||||
|---|---|---|---|---|---|---|---|---|---|---|
|
5-year |
Median, months |
P-value | ||||||||
| R0 | R1 | R0 | R1 | |||||||
| Steele et al.20 | 1991 | 87 | 1984–1988 | 37 | 21% | – | – | 37 | 21 | <0.01 |
| Cady et al.8 | 1998 | 244 | – | 37 | 16% | – | – | 18a | 9a | <0.05b |
| Fong et al.5 | 1999 | 1001 | 1985–1998 | – | 11% | 37% | 20% | 45 | 23 | <0.001b |
| Choti et al.1 | 2002 | 226 | 1984–1999 | – | 5% | – | – | 46 | 24 | 0.04b |
| Pawlik et al.3 | 2005 | 557 | 1990–2004 | 29 | 8% | 64% | 17% | NR | 49 | 0.01 |
| Nuzzo et al.19 | 2008 | 185 | 1992–2005 | 39 | 5% | 39% | 0% | 48 | 22 | 0.01 |
| de Haas et al.18 | 2008 | 436 | 1990–2006 | 40 | 46% | 61% | 57% | 77 | 84 | 0.27 |
a
Indicates disease-free survival
b
P remained significant (<0.05) on multivariate analysis
P-values shown in bold indicate <0.05
NR, not reached