Table 2. Expression of receptors for γc family cytokines and TSLP.
The expression of various cytokine receptors in different stages of the T cell immune response. γc is constitutively expressed by T cells. IL-2Rα is rapidly up-regulated in the early stage of T cell activation, thus augmenting the number of high-affinity IL-2Rs. The levels of expression of IL-2Rβ, IL-4Rα, IL-15Rα, IL-21R, and TSLPR are increased after T cell activation, and IL-2Rβ expression is sustained at a high level on CD8+ T memory cells.
|
type of T cells receptor chain |
Naive T cells | Effector T cells | Memory T cells |
|---|---|---|---|
| γc (CD132) | ++ | ++ | ++ |
| IL-2Rα (CD25) | − | +++ | − |
| IL-2Rβ (CD122) | + | +++ | +++ |
| IL-4Rα (CD124) | − | +++ | Nd |
| IL-7Rα (CD127) | ++ | −* | +++ |
| IL-15Rα | + | +++ | +++ |
| IL-21R | + | +++ | Nd |
| TSLPR** | + | ++ | Nd |
*
Only a few effector T cells express IL-7Rα.
**
The level of TSLPR expression on T cells is shown relative to expression on dendritic cells. Levels of IL-4Rα, IL-21R, and TSLPR on memory T cells have not been evaluated (nd, not done).