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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Bioconjug Chem. 2010 Jan;21(1):56. doi: 10.1021/bc900296z

Figure 4. (a) TOT-siRNA therapeutically reduces cholesterol levels.

Figure 4

Plasma cholesterol levels were measured 48 h after injecting mice with 0.96 mg/kg TOT-siRNA complex, (b) TOT-siRNA treatment does not induce interferon response in mice. IFN-α plasma levels were measured 48 h after injecting mice with 0.96 mg/kg TOT without siRNA (Mock) or with 0.96 mg/kg TOT-CM siRNA. As a positive control, IFN-α plasma levels were measured after Injecting mice with 250 μg Poly IC. Each value represents the mean ± SD of 5 plasma samples from each treatment group.