TABLE 1.
Clinical Characteristics and Task Force Criteria* of Patients With ARVD
| Characteristics | ARVD without CRBBB/IRB BB (n=68 ) |
ARVD with IRBBB (n= 15) |
ARVD with CRBBB (n= 17) |
ARVD (overall) (n=100) |
|---|---|---|---|---|
| Clinical Characteristics | ||||
| Age | 39 ± 16 | 38 ± 11 | 43 ± 14 | 39 ± 15 |
| Gender (Males)† | 33 (49) | 9 (60) | 15 (88) | 57 (57) |
| Task Force Criteria | ||||
| Family History | ||||
| Family History of ARVD confirmed by Biopsy or Autopsy | 15 (22) | 1 (7) | 1 (6) | 17 (17) |
| Family History of premature sudden death (<35 yrs) due to suspected ARVD | 14 (21) | 1 (7) | 0 (0) | 15 (15) |
| Family History (clinical diagnosis based on present criteria) | 18 (26) | 1 (7) | 2 (18) | 21 (21) |
| ECG depolarization/conduction abnormalities | ||||
| Epsilon waves | 5 (7) | 0 (0) | 0 (0) | 5 (5) |
| Localized QRS duration > 110ms in V1, V2 or V3 † | 48 (71) | 11 (73) | 12 (71) | 48 (48) |
| Late potentials on SAECG (n1= 57, n2= 10, n3= 11) | 42 (74) | 9 (90) | 10 (91) | 61 (78) |
| Repolarization abnormalities | ||||
| Inverted T waves in right precordial leads (V2–V3) above age 12 yrs | 60 (88) | 13 (87) | 15 (88) | 88 (88) |
| Tissue characterization of walls | ||||
| Fibrofatty replacement of myocardium in endomyocardial biopsy. (n1= 27, n2= 2, n3= 4) | 9 (33) | 2 (100) | 2 (50) | 13 (39) |
| Structural or Functional abnormalities | ||||
| Severe dilatation and reduction of RV ejection fraction with mild or no LV involvement † | 10 (15) | 6 (40) | 6 (35) | 22 (22) |
| Localized RV aneurysm | 14 (21) | 2 (13) | 5 (29) | 21 (22) |
| Mild global RV dilatation and/or ejection fraction reduction (localized RV disease) | 40 (59) | 7 (47) | 9 (53) | 56 (56) |
| Arrhythmias | ||||
| Left bundle branch block VT on ECG, Holter, or exercise tolerance test | 46 (68) | 14 (93) | 14 (82) | 74 (74) |
| Sustained VT (n1= 64, n2= 15, n3= 16) | 36 (56) | 11 (73) | 11 (69) | 58 (61) |
| Non sustained VT (n1= 58, n2= 13, n3= 16) | 41 (71) | 12 (92 ) | 13 (81 ) | 66 (76) |
| Frequent premature ventricular contractions (>1000/24 hrs Holter) (n1= 44, n2=10, n3= 9) | 30 (68) | 7 (70) | 5 (56) | 42 (67) |
LV indicates left ventricular. All values are in %
*
To be diagnosed as ARVD an individual must have 2 major, or 1 major plus 2 minor or 4 minor criteria n1= sample size of ARVD with no IRBBB/CRBBB, n2= sample size of ARVD with IRBBB, n3= sample size of ARVD with CRBBB. (when sample size different from 68, 15 and 17 respectively)
†
P < 0.05 (difference between groups)