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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Sex Med. 2009 Jun 9;6(9):2480. doi: 10.1111/j.1743-6109.2009.01349.x

Figure 2.

Figure 2

Immunohistochemical analysis of hedgehog-interacting protein (HIP) in the dorsal nerve bundle (A) and in the corpora cavernosa (B) of the penis of P7-P92 Sprague-Dawley rats. (a) HIP protein is localized in the nerves of the penis at all ages assayed. An unusual ultrastructure was observed in the nerves at P22 and P42. X250. (B) HIP was observed in a layer under the tunica at P7 (×1,000). HIP localization was restricted to the developing sinuses of the corpora cavernosa and individual cells between the sinuses that are likely fibroblasts at P12–P22 (×1,000) and at P42–P92 (×400). At P12, P22, and P42, intense HIP staining was observed in small structures within and between the developing smooth muscle cells. Arrows indicate HIP staining.