Figure 1.

Phylogenetic analysis of the Mob1 family. (A) A dendogram was constructed using Mob1 protein sequences from across multiple phyla (Supplemental Table 3), rooted to the basal eukaryote Giardia lamblia, with bootstrap values provided for each node. Based on this analysis and the nomenclature of Stavridi (Stavridi et al., 2003), vertebrate Mob1's were given the assignations Mob1A–E. Branches noted by the asterisks indicate possible gene duplications. (B) Amino acid alignment of the five human Mob1 isoforms. Identical residues are shaded in black, similar residues are shaded in gray and nonconserved residues are not shaded.