Table 2. Receptor affinity data for THC.
Receptors | hot ligand | source | tissue | Ki(nM) | Ref |
CB1 | 3H-BAY 38-7271 | HUMAN | CORTICAL MEMBRANES | 13.7 | PDSP; [27] |
3H-BAY 38-7271 | HUMAN | CLONED | 15.3 | PDSP; [28] | |
3H-CP-55940 | HUMAN | CLONED | 5.05 | PDSP; [29] | |
10.19 | average | ||||
CB2 | 3H-BAY 38-7271 | HUMAN | CLONED | 25.06 | PDSP; [28] |
3H-BAY 38-7271 | HUMAN | CLONED | 22.9 | PDSP; [27] | |
3H-CP-55940 | HUMAN | CLONED | 44.9 | [30] | |
3H-CP-55940 | HUMAN | CLONED | 3.13 | PDSP; [29] | |
16.85 | average | ||||
sigma | 3H-3-PPP,(+) | RAT | BRAIN | >100,000 | PDSP; [31] |
Receptor affinity data for THC collected from the literature. The columns identify the receptor, the radioligand used in determining affinity, the source species from which the receptor was used, the tissue from which the receptor was used, the Ki value in nanomoles, and the literature reference from which the data was obtained.