Skip to main content
. 2010 Feb 2;5(2):e9009. doi: 10.1371/journal.pone.0009009

Figure 1. Distinct probiotic strains prevents EAE and suppresses MOG-reactive T cells.

Figure 1

C57BL/6 mice received either L. paracasei DSM 13434, L. plantarum DSM 15312, L. plantarum DSM 15313 L. paracasei PCC 101, L. delbrueckii DSM 20081 (109 cfu, daily) or vehicle as control, starting 12 days prior to immunization for EAE. (A) The mean clinical score for each group of mice (n = 8) is shown. Data are representative of three separate experiments. (B) Spleen cell cultures from the probiotic-treated or control mice were restimulated in vitro with MOG35–55 peptide. MOG specific T cell proliferation was conducted with [3H]thymidine incorporation assay and each bar represents the mean stimulation index (± SEM) from triplicate measurements (n = 3). (C) Immunohistochemical staining for CD4+ T cells in sections from spinal cord isolated from L. paracasei DSM 13434-, L. plantarum DSM 15312-treated and control EAE animals at day 25 of immunization. In the histogram, each bar represents the mean percentage of stained area (± SEM). * represents a p-value≤0,05.