Fig. 3.

Differences in transcriptional regulation between HCPs and LCPs. (A, B) Bar plots showing the frequency of appearance of different histone modifications in best scoring three-modifications models for HCPs (B) (50 models) and LCPs (C) (40 models) in CD4+ T-cells. Best scoring models are defined as reaching at least 95% of prediction accuracy of the full model trained on HCPs and LCPs, respectively. Only the top ten modifications are depicted. (C) Normalized cumulative tag counts in the region of -500 base pairs to 3,000 base pairs surrounding the transcription start site of RefSeq genes in CD4+ T-cells for the five important modifications identified by our analysis.