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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Mol Pharm. 2010 Feb 1;7(1):138. doi: 10.1021/mp900177r

Figure 4. Steady-state uptake of several organic cations in MDCKII cells.

Figure 4

Intracellular accumulation of radiolabeled organic cations agmatine, TEA, and choline was significantly increased in bcrp1-transfected MDCKII cells, as compared to wild-type cells, consistent with the observed increase in OCT2 expression. Prazosin uptake, a representative positive control for bcrp1-mediated efflux, was significantly decreased in bcrp1 cells as compared to wild-type counterparts. Results are expressed as mean ± S.D (n = 3). (*p < 0.01 comparing with wild-type group)