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Directional Permeability of [3H]-agmatine in MDCKII Cell Monolayers
| Papp (10 -6 cm/s) | A-to-B | B-to-A | Influx Ratio (A-to-B/B-to A) |
|---|---|---|---|
| WT-MDCKII | 24.4 ± 1.5** | 3.29 ± 0.02 | 7.41 |
| bcrp1-MDCKII | 18.6 ± 0.6**!! | 3.35 ± 0.01 | 5.54## |
p < 0.01 compared with respective B-to-A permeability
p < 0.01 compared with WT A-to-B permeability
p < 0.01 compared with WT influx ratio
Results are expressed as mean ± S.D. (n = 3)
