Figure 1.
Time course of CFA-induced mechanical allodynia (A) and heat hypealgesia (B) in rats. CFA produces rapid (<1 hour) and persistent (>2 weeks) mechanical allodynia in both ipsilateral and contralateral paws (A). CFA only induces ipsilateral heat hyperalgesia, which largely recovers after 2 weeks (B). *, P<0.05; **, P<0.01, compared to pre-CFA baseline, n = 6.