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. Author manuscript; available in PMC: 2010 Feb 2.
Published in final edited form as: Pain. 2010 Feb;148(2):309. doi: 10.1016/j.pain.2009.11.017

Figure 8.

Figure 8

CFA-induced mechanical allodynia is reduced in mice lacking JNK1. CFA produced rapid and persistent bilateral mechanical allodynia (A, B) and ipsilateral heat hyperalgesia (C, D) in wild-type mice. But in JNK1−/− mice, mechanical allodynia is attenuated bilaterally, especially in the maintenance phase (A, B). CFA-induced heat hyperalgeisa is comparable in wild-type and JNK1−/− mice (C, D). *, P<0.05; **, P<0.01; compared to wild type mice at the corresponding time points. Notice that the baseline pain sensitivity is normal in the knockout mice. n = 7–8.