Table 3.
Multivariate Relationships between Chronic Kidney Disease-related symptoms and cohort characteristics
| Weakness % OR (95% CI) |
Waking Up Early % OR (95% CI) |
Falling Asleep during the day % OR (95% CI) |
Decreased Alertness % OR (95% CI) |
|
|---|---|---|---|---|
| No. | No.=224 | No.=264 | No.=246 | No.=268 |
| Measured GFR a | ||||
| ≥50 | 29%; 1 (ref) | 33%; 1 (ref) | 31%; 1 (ref) | 31%; 1 (ref) |
| 40-<50 | 22%; 2.08 (0.79, 5.47) | 22%; 2.29 (0.99, 5.32) | 21%; 2.95 (1.26, 6.88)* | 23%; 1.02 (0.31, 3.36) |
| 30-<40 | 26%; 1.60 (0.59, 4.37) | 24%; 1.13 (0.44, 2.88) | 25%; 1.94 (0.79, 4.77) | 23%; 1.44 (0.46, 4.48) |
| <30 | 23%; 3.92 (1.37, 11.17)* | 22%; 0.36 (0.10, 1.34) | 23%; 2.15 (0.83, 5.57) | 23%; 1.40 (0.41, 4.74) |
| Demographics | ||||
| Age (years) | ||||
| 8 to ≤11 | NA | NA | 30%; 1 (ref) | 28%; 1 (ref) |
| >11 to ≤14 | NA | NA | 24%; 1.59 (0.65, 3.89) | 24%; 3.50 (0.98, 12.57) |
| >14 to ≤16 | NA | NA | 21%; 4.34 (1.63, 11.60)* | 22%; 3.07 (0.86, 10.96) |
| >16 | NA | NA | 26%; 5.27 (1.75, 15.85)* | 26%; 2.44 (0.68, 8.67) |
| non-White Race | NA | NA | NA | 26%; 1.71 (0.72, 4.05) |
| Family Income | ||||
| ≤ $36,000 | 36%; 1 (ref) | 37%; 1 (ref) | 37%; 1 (ref) | NA |
| $36,000–<$75,000 | 31%; 0.44 (0.20, 0.97)* | 31%; 0.52 (0.21, 1.29) | 31%; 0.47 (0.22, 0.98)* | NA |
| >$75,000 | 33%; 0.39 (0.17, 0.89)* | 31%; 0.90 (0.41, 1.98) | 32%; 0.51 (0.25, 1.02) | NA |
| % of life with CKD | ||||
| <25% | 17%; 1 (ref) | NA | NA | 17%; 1 (ref) |
| 25% to <75% | 26%; 0.18 (0.07, 0.51)* | NA | NA | 29%; 0.73 (0.26, 2.04) |
| 75% to 100% | 56%; 0.29 (0.13, 0.68)* | NA | NA | 54%; 0.55 (0.20, 1.48) |
| Growth Markers | ||||
| Birth Weight <2500g** | 19%; 2.74 (1.23, 6.06)* | NA | NA | NA |
| BMI percentile b | ||||
| <35 | 25%; 1 (ref) | NA | NA | NA |
| 35 to <60 | 26%; 0.79 (0.33, 1.87) | NA | NA | NA |
| 60 to <85 | 23%; 0.84 (0.33, 2.12) | NA | NA | NA |
| ≥85 | 26%; 0.57 (0.21, 1.50) | NA | NA | NA |
| Tanner Stage IV or V | 37%; 0.54 (0.27, 1.10) | NA | 37%; 0.56 (0.24, 1.31) | NA |
| Anemia | 44%; 2.20 (1.05, 4.63)* | NA | 43%; 1.33 (0.68, 2.59) | 43%; 1.88 (0.77, 4.55) |
| Global P-value for model significance |
P<0.001 | P=0.02 | P=0.001 | P=0.3 |
OR, odds ratio; CI, confidence interval; CKD, chronic kidney Disease; NA, not applicable.
a
Glomerular filtration Rate measured in ml/min/1.73m2.
b
Age and sex specific percentiles using standard growth charts for United States children
*
indicates significance at the 0.05 level
**
reference value is ≥2500 g