Table 3.
ELISA | PRNT | |||||||
---|---|---|---|---|---|---|---|---|
Group | Day | Na | n (%)b | GMTc | 95% CI (LLe - ULf) | n (%)b | GMTc | 95% CI (LLe-ULf) |
Group 1 2×107 TCID50 | 0 | 54 | 0 (0%) | 1.0 | NA | 0 (0%) | 1.00 | NA |
28 | 54 | 32 (59.3%) | 14.4 | 7.7 – 26.8 | 4 (7.4%) | 1.31 | 1.01 – 1.70 | |
42 | 54 | 54 (100%) | 377.2 | 288.3 – 493.5 | 23 (42.6%) | 5.51 | 3.17 – 9.59 | |
84 | 54 | 51 (94.4%) | 134.3 | 91.1 – 198.2 | 10 (18.5%) | 1.94 | 1.31 – 2.85 | |
Group 2 5×107 TCID50 | 0 | 49 | 0 (0%) | 1.00 | NA | 0 (0%) | 1.00 | NA |
28 | 49 | 40 (81.6%) | 53.2 | 29.9 – 94.9 | 6 (12.2%) | 1.55 | 1.10 – 2.19 | |
42 | 49 | 49 (100%) | 583.6 | 461.6 – 737.9 | 29 (59.2%) | 10.31 | 5.78 – 18.40 | |
84 | 49 | 49 (100%) | 227.8 | 176.4 – 294.1 | 11 (22.4%) | 2.32 | 1.47 – 3.66 | |
Group 3 1×108 TCID50 | 0 | 52 | 0 (0%) | 1.0 | NA | 0 (0%) | 1.00 | NA |
28 | 52 | 49 (94.2%) | 98.5 | 67.6 – 143.7 | 5 (9.6%) | 1.39 | 1.05 – 1.85 | |
42 | 52 | 52 (100%) | 813.8 | 628.7 – 1053.3 | 37 (71.2%) | 19.43 | 11.05 – 34.16 | |
84 | 52 | 52 (100%) | 323.6 | 246.8 – 424.3 | 15 (28.8%) | 2.94 | 1.81 – 4.76 |
N = number of subjects with samples for antibody response; PP = per protocol
n (%) = number (percentage) of seropositive subjects (PRNT titres ≥ 20, ELISA titres ≥ 50)
GMT = Geometric Mean Titre
CI = confidence interval
LL = lower limit
UL = upper limit