Table 3.

ELISA and PRNT seroconversion rates and GMT (PP population, N = 155)

			ELISA			PRNT
Group	Day	Na	n (%)b	GMTc	95% CI (LLe - ULf)	n (%)b	GMTc	95% CI (LLe-ULf)
Group 1 2×107 TCID50	0	54	0 (0%)	1.0	NA	0 (0%)	1.00	NA
	28	54	32 (59.3%)	14.4	7.7 – 26.8	4 (7.4%)	1.31	1.01 – 1.70
	42	54	54 (100%)	377.2	288.3 – 493.5	23 (42.6%)	5.51	3.17 – 9.59
	84	54	51 (94.4%)	134.3	91.1 – 198.2	10 (18.5%)	1.94	1.31 – 2.85
Group 2 5×107 TCID50	0	49	0 (0%)	1.00	NA	0 (0%)	1.00	NA
	28	49	40 (81.6%)	53.2	29.9 – 94.9	6 (12.2%)	1.55	1.10 – 2.19
	42	49	49 (100%)	583.6	461.6 – 737.9	29 (59.2%)	10.31	5.78 – 18.40
	84	49	49 (100%)	227.8	176.4 – 294.1	11 (22.4%)	2.32	1.47 – 3.66
Group 3 1×108 TCID50	0	52	0 (0%)	1.0	NA	0 (0%)	1.00	NA
	28	52	49 (94.2%)	98.5	67.6 – 143.7	5 (9.6%)	1.39	1.05 – 1.85
	42	52	52 (100%)	813.8	628.7 – 1053.3	37 (71.2%)	19.43	11.05 – 34.16
	84	52	52 (100%)	323.6	246.8 – 424.3	15 (28.8%)	2.94	1.81 – 4.76

^aN = number of subjects with samples for antibody response; PP = per protocol

^bn (%) = number (percentage) of seropositive subjects (PRNT titres ≥ 20, ELISA titres ≥ 50)

^cGMT = Geometric Mean Titre

^dCI = confidence interval

^eLL = lower limit

^fUL = upper limit