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. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Brain Res Bull. 2009 Nov 6;81(2-3):310. doi: 10.1016/j.brainresbull.2009.10.018

Figure 6.

Figure 6

A–C. The effect of amfenac, celecoxib, and SC-560 on VEGF-induced HRMEC tube formation. (A) HRMEC tube formation was induced by 25 ng/ml VEGF, and this induction was significantly inhibited by amfenac (* p ≤ 0.001), the COX-2-selective NSAID celecoxib (* p ≤ 0.001; † p ≤ 0.006), and, at higher concentrations, the COX-1 selective NSAID SC-560 (* p ≤ 0.001; ‡ p ≤ 0.01). Each bar represents the mean ± SD. (B) A representative image of tube formation in VEGF-stimulated HRMEC. (C) A representative image of tube formation in VEGF-stimulated HRMEC treated with 1 μM amfenac. Amfenac-treated HRMEC demonstrate reduced tube formation.