Fig. 7.
Structure of HIV-1 CA. (A) Structure of monomeric CA, with the CANTD (green) and CACTD (blue/green) indicated. The interdomain linker, N- and C-termini, and cyclophilin A binding loop are shown. Helices 1-11 and the N-terminal β-hairpin (yellow) are labeled. Binding sites for CAP1 and CAI/NYAD-1/NYAD-13 are indicated by red and black arrows, respectively. Reprinted with permission from Elsevier (Ganser-Pornillos, Yeager, and Sundquist, 2008). (B) Molecular model of the CANTD hexameric ring; cyclophilin A binding loop indicated with an arrow. (C) Outside view of an assembled CA tube, showing the CA hexameric lattice. One CA hexamer is shown in yellow. Scale bar = 100 Å. (D) Molecular model of an HIV-1 conical core. A line of hexamers is shown in yellow; pentamers are depicted in red at each end of the conical core. Adapted with permission from Macmillan Publishers Ltd: [Nature], (Li et al., 2000), http://www.nature.com/nature/index.html.