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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Exp Mol Pathol. 2009 Oct 2;88(1):210. doi: 10.1016/j.yexmp.2009.09.013

Figure 1. Soluble PECAM chimera reduces inflammation in collagen antibody induced arthritis.

Figure 1

Ankle thickness measurements (in mm) are shown throughout the time course of CAIA. On Day -3 (not shown), mice received either 4 mg of arthrogen antibody cocktail or PBS. The mice in the top panels received arthrogen (10 mice per group) whereas the mice in the bottom panels received PBS (5 mice per group). All mice received 50 µg of LPS on day 0. Starting at day 2 (arrow Rx,) all mice that received arthrogen or PBS were randomized into two treatment groups that received 100 µg of either human IgG1 (left column) or mPECAM-Fc (right column) intraperitoneally. A) Mice were treated with mPECAM-Fc or human IgG1 (huIgG1) every other day. The total area under the curve is significantly less for the arthrogen mice that received PECAM-Fc (12.49 arbitrary units) compared to arthrogen mice that received human IgG1 (23.35 arbitrary units). B) Mice were treated every third day. The total area under the curve is significantly less for the arthrogen mice that received PECAM-Fc (11.57 arbitrary units) compared to arthrogen mice that received human IgG1 (22.24 arbitrary units).