Table.
Ad.β1AR vs Control | Ad.AC6 vs Control | |
---|---|---|
Transgene location | PM | PM, NE, SR, MM, Cytoplasm |
Follistatin family proteins | Increased 4-fold | No change |
Phospho-p38 | Increased 3-fold | No change |
Phosphatidylserine translocation |
To external PM, marked |
No change |
PKA & EPAC activity/expression |
No change | No change |
PHLPP2 activity | No change | Inhibited |
Akt activity | No change | Increased 5-fold |
p70S6 kinase phosphorylation | Decreased | Increased 2-fold |
Bcl2 expression | No change | Increased 2-fold |
Apoptosis | Increased 2-4 fold | No change |
PM, plasma membrane; NE, nuclear envelope; SR, sarcoplasmic reticulum; MM, mitochondrial membrane. The findings are summary of data from three or more experimental repeats.