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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: J Neurosci Methods. 2009 Oct 20;185(2):264. doi: 10.1016/j.jneumeth.2009.10.008

Figure 5. Dynamic Oscillations of extracellular glutamate in awake NHPs measured with real-time (2 Hz) amperometry.

Figure 5

A) Traces showing current measured on ‘glutamate-sensitive’ (black line) and sentinel (dashed line) recording sites. The first recordings and follow-ups were four months apart. B) Self-referenced glutamate levels were determined by subtraction of current recorded by sentinel sites from current recorded by glutamate-sensitive sites. The resulting current value was divided by the MEA sensitivity to glutamate (pA/µM) determined during electrode calibration prior to each experiment. Self-referencing increased the signal-to-noise ratio by mathematically removing noise of both electrical and mechanical origins.