Table 3.
Coagulation parameters measured before (Oxygen Debt = 0 ml/kg) and during traumatic hemorrhagic shock (Oxygen Debt 40 and 80 ml/kg).
| Oxygen Debt (ml/kg) | |||
|---|---|---|---|
| Variable, Mean(SE) | 0 | 40 | 80 |
| Coagulation | |||
| PT (sec) | |||
| Hem | 13.0(0.5) | 13.8(0.6) | 13.3(0.5) |
| Sham | 13.8(0.6) | 13.0(0.6) | 12.6(0.6) |
| PTT (sec) | |||
| Hem | 26.2(1.7) | 25.4(2.0) | 23.7(1.9) |
| Sham | 25.5(2.2) | 22.5(2.0) | 22.3(2.0) |
| Fibrinogen (mg/dl) | |||
| Hem | 153.3(8.3) | 93.4(9.9)*† | 94.1(8.8)*† |
| Sham | 174.1(11.6) | 159.6(13.0) | 173.8(13.0) |
| Thrombelastrography | |||
|---|---|---|---|
| R Time (min) | |||
| Hem | 5.3(0.4) | 4.4(0.5) | 5.2(0.4) |
| Sham | 4.5(1.0) | 4.9(0.7) | 4.6(0.7) |
| K Time (min) | |||
| Hem | 1.5(0.1) | 1.3(0.1) | 1.5(0.1) |
| Sham | 1.2(0.2) | 1.2(0.2) | 1.3(0.2) |
| Ang (deg) | |||
| Hem | 70.3(1.3) | 73.0(1.5) | 69.5(1.4) |
| Sham | 75.1(3.0) | 74.2(2.4) | 73.8(2.3) |
| MA (mm) | |||
| Hem | 68.8(0.9) | 67.2(1.0) | 64.7(0.9)*† |
| Sham | 69.8(2.1) | 70.6(1.6) | 70.6(1.6) |
PT= Prothrombin Time, PTT= Partial Thromboplastin Time, Thrombelastography parameters; R= Clot initiation time, K = fibrin polymerization time, Ang = rate of fibrin polymerization/cross linking, MA = Maximal Amplitude of deflection representing clot strength as sum of fibrin network strength and platelet contraction.
*
= different than OD= 0 cc/kg, p value < 0.05,
†
=different than corresponding Sham sample, p value < 0.05