Table 2.
Frequency of gene promoter methylation in cfpDNA
| A. RRMS(r/c) pattern | ||
|---|---|---|
| Gene | RRMS(r) | Controls |
| %Methylated | %Methylated | |
| CDH1# | 38.7 | 0.0 |
| CDKN2A* | 22.6 | 0.0 |
| CDKN2B# | 71.0 | 22.6 |
| FAS* | 61.3 | 25.8 |
| ICAM1 | 19.4 | 0.0 |
| MCJ* | 51.6 | 12.9 |
| MDGI* | 32.3 | 0.0 |
| MUC2 | 90.3 | 64.5 |
| MYF3 | 61.3 | 90.3 |
| PAX5 | 58.1 | 19.4 |
| PGK1* | 64.5 | 16.1 |
| RB1 | 38.7 | 67.7 |
| SOCS1 | 32.3 | 6.5 |
| SYK# | 77.4 | 22.6 |
| TP73* | 35.5 | 0.0 |
| B. RRMS(e/c) pattern | ||
|---|---|---|
| Gene | RRMS(e) | Controls |
| %Methylated | %Methylated | |
| BRCA1 | 55.2 | 16.7 |
| CCND2 | 24.1 | 0.0 |
| DAPK | 25.9 | 0.0 |
| FAS* | 69.0 | 22.2 |
| FHIT | 48.3 | 16.7 |
| MCT1 | 71.4 | 33.3 |
| MDGI* | 25.0 | 0.0 |
| MCJ* | 53.6 | 14.3 |
| CDKN2A* | 48.3 | 0.0 |
| TP73* | 27.6 | 0.0 |
| PGK1* | 58.6 | 17.9 |
| PR PROX** | 48.3 | 13.3 |
| C. RRMS(r/e) pattern | ||
|---|---|---|
| Gene | RRMS(e) | RRMS(r) |
| %Methylated | %Methylated | |
| CDH1# | 6.7 | 38.7 |
| CDKN2B# | 33.3 | 71.0 |
| HIC1 | 76.7 | 32.3 |
| PR PROX** | 46.7 | 12.9 |
| SYK# | 46.7 | 77.4 |
RRMS(r)= RRMS patients in remission; RRMS(e)=RRMS patients in exacerbation;
*
Gene promoters that were informative in both RRMS(r/c) and RRMS(e/c) patterns;
#
Gene promoters that were informative in both RRMS(r/c) and RRMS(r/e) patterns;
**
Gene promoters that were informative in both RRMS(e/c) and RRMS(r/e) patterns