Table 4.
Differentially methylated gene promoters in RRMS patterns.
| Comparison | Promoters present in more than one pattern | Promoters specific to only one pattern | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RRMS(r/c) | CDKN2A | FAS | MCJ | MDGI | PGK1 | TP73 | CDH1 | CDKN2B | SYK | ICAM1 | MUC2 | MYF3 | PAX5 | RB1 | SOCS1 | |
| RRMS(e/c) | CDKN2A | FAS | MCJ | MDGI | PGK1 | TP73 | PR prox | BRCA1 | CCND2 | DAPK | FHIT | MCT1 | ||||
| RRMS(e/r) | CDH1 | CDKN2B | PR prox | SYK | HIC1 | |||||||||||
A composite of all three comparisons summarizing the gene promoters common to both remission and exacerbation and unique to disease status. RRMS (r/c) pattern = RRMS patients in remission vs. healthy controls. RRMS(e/c) pattern = RRMS patients in exacerbation vs. healthy controls, RRMS(e/r) pattern = RRMS patients in exacerbation vs. RRMS patients in remission.