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. Author manuscript; available in PMC: 2011 Jan 22.
Published in final edited form as: Vaccine. 2009 Nov 13;28(4):1031. doi: 10.1016/j.vaccine.2009.10.126

Table 1.

Gamma Irradiation of V3526 – Loss of Infectivity and Retention of Epitope Integrity

V3526 BDSE Infectivityb of
Starting
Concentration
(pfu/mL)		 Infectivityb Post
Irradiation
(pfu/mL)		 IC
Inoculation
(Survived/
Inoculated)		 Epitope
Integrity
(% of Controld)
Untreated 3 × 107 3 × 107 0/13 100
Irradiated DEVa
Lot 220		 3 × 107 BLDc 13/13 32
Irradiated DEV
Lot 225		 3 × 108 BLDc 13/13 50
PCM 0 ND e 12/12 NDe
a

Development (DEV) lots 225 and 220 were each irradiated at 50 kGy gamma irradiation

b

Plaque assay on Vero cell monolayers

c

BLD = below limit of detection (< 3 pfu/mL) in Vero cell assay

d

Untreated V3526 BDS served as control for the ELISA

e

Not done