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Complex regulation of OGT and O-GlcNAcase. OGT and O-GlcNAcase can form very dynamic complexes with each other and/or kinases and phosphatases under different cellular signalings. Transient complex formation between O-GlcNAc regulatory enzymes and various binding partners enables a highly sensitive regulation of GlcNAcylation in response to specific cellular conditions. OGT: purple, O-GlcNAcase: blue, Kinase: red, Phosphatase: yellow.
