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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Mol Immunol. 2009 Dec 8;47(5):1083. doi: 10.1016/j.molimm.2009.11.003

Fig. 4.

Fig. 4

Role of the ectodomain in mediating TLR8 activation. (A) A schematic of the human and mouse TLR8 chimera constructs. ECD, extracellular domain/ectodomain; TM, transmembrane domain; TIR, Toll-interleukin 1 receptor domain. (B) Ectodomain determines response of TLR8 to ligand stimulation. HEK293 cells were transfected with different TLR8 expression vectors as indicated, plus ELAM luciferase-reporter gene, and stimulated with 2 μM of CL075. Relative luciferase activities were determined. Data shown represent mean ± SD (n=3). *P < 0.05 vs. cells transfected with hTLR8 wt plasmid.