. Author manuscript; available in PMC: 2011 Feb 1.

Published in final edited form as: Trends Pharmacol Sci. 2009 Dec 4;31(2):66. doi: 10.1016/j.tips.2009.10.010

Table 2.

Segmental trisomy mouse models of DS

Mouse model	[Ref]	Chr	# Mb	^aRefSeqP		^bBehavior		^cElectrophysiology; cellular
Mouse model	[Ref]	Chr	# Mb	#	Boundaries	Deficits	Normal	Abnormal	Normal
Ts1Yu	[14]	MMU16		104	Lip1-Znf295	ND		ND
Ts65Dn	[13]	MMU16	16	94	Mrpl39-Znf295	MWM, CFC, NOR, TM		LTP, LTD, BFCN, CB-GC
Ts1Cje	[13, 22]	MMU16	8	75	>Sod1-Znf295	MWM, CFC, TM	NOR	LTP, CB-GC	BFCN
Ts1Rhr	[15, 23]	MMU16	3	35	Cbr1-M×2	NOR, TM	MWM	LTP	LTP-CA1 CB-GC
Ts1Yah	[16]	MMU17	0.5	12	Abcg1-U2af1	NOR	MWM^*		LTP^*
Tc1	[17, 24]	HSA21	∼30		DEL: CXADR; IFNGR1, ITSN1, KCNE1, RCAN1	NOR-stm, MWM-stm	NOR-Ltm, MWM-Ltm; TM	LTP-1; CB-GC	LTP-24

RefSeqP: # of curated protein coding genes in the orthologous region of HSA21q. Boundaries: genes at the centromeric and telomeric ends of the trisomic segment.

Behavior: see Box 1. Stm, short term memory; Ltm, long term memory.

LTP, long term potentiation; LTP-1, LTP-24, LTP measured at one and 24 hours after initial stimulation. LTD, long term depression; BFCN, basal forebrain cholinergic neurons; CB-GC, cerebellar granule cells.

, enhanced compared with euploid controls.