Table 3.
Gene Ontology data mining analysis of the genes differentially expressed after RGC-32 knockdown in SW480 cells.
| Description | Number of genes | % | p-value | Benjamini |
|---|---|---|---|---|
| Chromatin assembly | 10 | 5.3 | 1.00E-06 | 5.40E-03 |
| Nucleosome assembly | 9 | 4.8 | 3.70E-06 | 9.60E-03 |
| Chromatin assembly or disassembly | 10 | 5.3 | 1.90E-05 | 3.30E-02 |
| Chromosome organization and biogenesis | 15 | 7.9 | 5.70E-05 | 7.20E-02 |
| Protein-DNA complex assembly | 9 | 4.8 | 1.90E-04 | 1.80E-01 |
| Organelle organization and biogenesis | 27 | 14.3 | 2.10E-04 | 1.70E-01 |
| Establishment and/or maintenance of chromatin architecture | 12 | 6.3 | 4.20E-04 | 2.70E-01 |
| DNA packaging | 12 | 6.3 | 4.90E-04 | 2.80E-01 |
| DNA metabolic process | 21 | 11.1 | 5.30E-04 | 2.70E-01 |
| Cellular component organization and biogenesis | 41 | 21.7 | 1.00E-02 | 1.00E+00 |
| Cell proliferation | 16 | 8.5 | 1.70E-02 | 1.00E+00 |
| RNA processing | 11 | 5.8 | 2.00E-02 | 1.00E+00 |
| Cellular component assembly | 13 | 6.9 | 2.20E-02 | 1.00E+00 |
| Cell cycle process | 15 | 7.9 | 2.20E-02 | 1.00E+00 |
| RNA splicing | 7 | 3.7 | 3.00E-02 | 1.00E+00 |
| Macromolecular complex assembly | 12 | 6.3 | 3.00E-02 | 1.00E+00 |
| Cellular iron ion homeostasis | 3 | 1.6 | 3.60E-02 | 1.00E+00 |
| Pigment biosynthetic process | 3 | 1.6 | 4.30E-02 | 1.00E+00 |
| Regulation of progression through cell cycle | 11 | 5.8 | 4.50E-02 | 1.00E+00 |
| Pigment metabolic process | 3 | 1.6 | 5.30E-02 | 1.00E+00 |
| Smooth muscle contraction | 3 | 1.6 | 5.80E-02 | 1.00E+00 |
| Protein localization | 14 | 7.4 | 6.40E-02 | 1.00E+00 |
| Defense response to bacterium | 4 | 2.1 | 6.70E-02 | 1.00E+00 |
| Regulation of cell proliferation | 10 | 5.3 | 7.30E-02 | 1.00E+00 |
| Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 51 | 27 | 8.00E-02 | 1.00E+00 |
| Ectoderm development | 5 | 2.6 | 8.20E-02 | 1.00E+00 |
| Establishment of protein localization | 13 | 6.9 | 8.30E-02 | 1.00E+00 |
| Mitosis | 6 | 3.2 | 8.50E-02 | 1.00E+00 |
| Secondary metabolic process | 3 | 1.6 | 9.00E-02 | 1.00E+00 |
| Macromolecule localization | 14 | 7.4 | 9.30E-02 | 1.00E+00 |
| Metabolic process | 104 | 55 | 9.40E-02 | 1.00E+00 |
| Lipid metabolic process | 13 | 6.9 | 9.50E-02 | 1.00E+00 |
| Cofactor metabolic process | 6 | 3.2 | 9.70E-02 | 1.00E+00 |