Skip to main content
. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Exp Mol Pathol. 2009 Oct 27;88(1):52. doi: 10.1016/j.yexmp.2009.10.006

Fig. 4.

Fig. 4

Manipulation of actin cytoskeleton affects VSMC differentiation in vitro. (A) latrunculin B (LatB, 0.5 µM for 6 hours) and Jasplakinolide (Jasp, 0.3 µM for 6 hours) induce significant morphology changes of PAC1 cells. (B–C) LatB and Jasp respectively reduce and enhance the transcription of VSMC-specific markers, SRF and myocardin by the real-time RT-PCR assay (B) and VSMC promoter activities (C) in PAC1 cells treated with LatB or Jasp for 6 hours. * and ** indicate p<0.05 and p<0.01 vs control.