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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Exp Mol Pathol. 2009 Oct 27;88(1):52. doi: 10.1016/j.yexmp.2009.10.006

Fig. 5.

Fig. 5

A potential mechanism for organ culture-induced early phenotypic modulation of VSMC. During organ culture, loss of tensile stress induces actin cytoskeleton dissociation that then leads to decreased expression of SRF and Myocd and the downregulation of VSMC gene transcription.