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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Pharmacol Ther. 2009 Aug 31;125(1):27. doi: 10.1016/j.pharmthera.2009.07.007

Figure1.

Figure1

The roles that PRR is proposed to have, in the cardiovascular regulatory centers in the brain to mediate control of BP. PRR is hypothesized to facilitate localized tissue RAS function. 1) By binding and sequestering renin or prorenin in the brain, PRR increases the catalytic efficiency of 2) Agt conversion to Ang I. In this way the PRR is hypothesized to mitigate the limited expression of renin in the brain. 3) Membrane bound ACE, which is expressed in the brain, will then convert Ang I to Ang II in order to 4) stimulate the AT1R.