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. Author manuscript; available in PMC: 2011 Feb 5.
Published in final edited form as: Mol Cell Endocrinol. 2009 Sep 17;315(1-2):246. doi: 10.1016/j.mce.2009.09.010

Fig. 6.

Fig. 6

Developmental analysis of Tcam1 null and heterozygous animals. Testes were harvested from B6;129S5 (A) and 129S5 (B) mice ranging in age from 2 to 7 weeks. Body weights versus testis weights were plotted for both genotypes, and the linear regression analysis of each group was compared. The 129S5-Tcam1-/- group differed significantly (p<0.002) from the heterozygous control group due to the presence of three outliers (B, red circle). Histological analysis of representative B6;129S5 testes at 3 weeks-old (C, D), 6 weeks-old (E, F), and adult (G, H) show comparable germ cell development in Tcam1 heterozygous (C, E, G) and null (D, F, H) mice. In contrast, one of the 129S5-Tcam1-/- outliers shows variable progression of spermatogenesis and germ cell sloughing (F, inset). C-H, 100× magnification; F, inset, 200× magnification.