Table 3.
Hazard ratios for risk of secondary cerebral ischemia and rebleeding after aneurysmal subarachnoid hemorrhage according to genotype
| Genotype | Complication | No complication | Crude hazard ratio (95% CI) | Adjusted hazard ratio (95% CI)* |
|---|---|---|---|---|
| FV Leiden | Secondary cerebral ischemia | No secondary cerebral ischemia | ||
| GG | 45 (23.0%) | 151 (77.0%) | 1 (reference) | 1 (reference) |
| GA and AA | 4 (36.4%) | 7 (63.6%) | 1.8 (0.6–4.9) | 1.8 (0.6–5.0) |
| Rebleeding | No rebleeding | |||
| GG | 26 (13.2%) | 171 (86.8%) | 1 (reference) | |
| GA and AA | 1 (9.1%) | 10 (90.9%) | 0.6 (0.1–4.5) | NA |
| Prothrombin G20210A | Secondary cerebral ischemia | No secondary cerebral ischemia | ||
| GG | 48 (24.0%) | 152 (76.0%) | 1 (reference) | 1 (reference) |
| GA and AA | 1 (14.3%) | 6 (85.7%) | 0.5 (0.1–3.9) | 0.5 (0.1–3.9) |
| Rebleeding | No rebleeding | |||
| GG | 27 (13.4%) | 174 (86.6%) | 1 (reference) | |
| GA and AA | 0 (0%) | 7 (100%) | 0.7 (0.1–5.4) | NA |
| MTHFR C677T | Secondary cerebral ischemia | No secondary cerebral ischemia | ||
| CC and CT | 47 (25.4%) | 138 (74.6%) | 1 (reference) | 1 (reference) |
| TT | 2 (9.1%) | 20 (90.9%) | 0.4 (0.1–1.5) | 0.4 (0.1–1.5) |
| Rebleeding | No rebleeding | |||
| CC and CT | 22 (11.9%) | 163 (88.1%) | 1 (reference) | |
| TT | 4 (18.2%) | 18 (81.8%) | 0.6 (0.2–1.7) | NA |
| FXIII A Val34Leu | Secondary cerebral ischemia | No secondary cerebral ischemia | ||
| ValVal | 30 (24.62%) | 92 (75.4%) | 1 (reference) | 1 (reference) |
| ValLeu and LeuLeu | 18 (20.9%) | 68 (79.1%) | 0.9 (0.5–1.6) | 0.9 (0.5–1.6) |
| Rebleeding | No rebleeding | |||
| ValVal | 14 (11.4%) | 109 (88.6%) | 1 (reference) | |
| ValLeu and LeuLeu | 14 (16.3%) | 72 (83.7%) | 1.2 (0.5–2.6) | NA |
| FXIII A Tyr204Phe | Secondary cerebral ischemia | No secondary cerebral ischemia | ||
| TyrTyr | 44 (23.4%) | 144 (76.6%) | 1 (reference) | 1 (reference) |
| TyrPhe and PhePhe | 4 (21.1%) | 15 (78.9%) | 0.9 (0.3–2.4) | 0.9 (0.3–2.4) |
| Rebleeding | No rebleeding | |||
| TyrTyr | 27 (14.3%) | 162 (85.7%) | 1 (reference) | |
| TyrPhe and PhePhe | 1 (5.3%) | 18 (94.7%) | 0.3 (0.0–2.5) | NA |
| FXIII A Pro564Leu | Secondary cerebral ischemia | No secondary cerebral ischemia | ||
| ProPro | 31 (27.2%) | 83 (72.8%) | 1 (reference) | 1 (reference) |
| ProLeu and LeuLeu | 17 (21.3%) | 63 (78.8%) | 0.8 (0.4–1.4) | 0.8 (0.4–1.4) |
| Rebleeding | No rebleeding | |||
| ProPro | 12 (10.5%) | 102 (89.5%) | 1 (reference) | |
| ProLeu and LeuLeu | 14 (17.5%) | 66 (82.5%) | 1.8 (0.8–4.2) | NA |
| FXIII B His95Arg | Secondary cerebral ischemia | No secondary cerebral ischemia | ||
| HisHis | 33 (21.9%) | 118 (78.1%) | 1 (reference) | |
| HisArg and ArgArg | 14 (31.1%) | 31 (68.9%) | 1.5 (0.8–2.8) | 1.6 (0.8–2.9) |
| Rebleeding | No rebleeding | |||
| HisHis | 18 (11.8%) | 134 (88.2%) | 1 (reference) | |
| HisArg and ArgArg | 8 (17.8%) | 37 (82.2%) | 1.1 (0.4–2.9) | NA |
*Adjusted for clinical condition on admission and amount of blood on initial CT scan.
CI = confidence interval; NA = not applicable