TABLE 1.
Baseline characteristics of healthy participants and TB patientsa
| Characteristic | Control subjects (n = 36) | TB patients (n = 32) | P |
|---|---|---|---|
| Age (yr)b | 40.0 (36.3, 70.3) | 52.5 (40.5, 75.8) | 0.117 |
| Genderc | 0.866 | ||
| Male | 31 (86.1) | 28 (87.5) | |
| Female | 5 (13.9) | 4 (12.5) | |
| Smokingd | 0.652 | ||
| Never | 25 (69.4) | 24 (75.0) | |
| Previous | 3 (8.3) | 1 (3.1) | |
| Current | 8 (22.2) | 7 (21.9) | |
| Severity of lung disease | |||
| Limited | 14 (43.8) | NA | |
| Extended | 18 (56.3) | ||
| Lung pattern | |||
| Coalescent | 21 (65.6) | NA | |
| Infiltrative | 11 (34.4) | ||
| AFB smear result | |||
| Negative | 21 (65.6) | NA | |
| Positive | 11 (34.4) | ||
| Cytokine concn (pg/ml) | |||
| TNF-αb | 28.9 (28.6, 40.3) | 34.7 (32.8, 38.9) | 0.001* |
| IL-6b | 9.3 (9.2, 9.6) | 9.6 (9.2, 11.1) | 0.024* |
| IL-8b | 750.4 (731.6, 763.4) | 901.2 (797.6, 2,267.4) | <0.001* |
| IL-10b | 30.2 (28.9, 35.7) | 30.4 (28.8, 32.4) | 0.610 |
| IL-12b | 183.2 (178.0, 199.4) | 192.9 (189.1, 198.5) | 0.005* |
| MCP-1b | 2,793.2 (2,778.2, 2,853.5) | 3,717.2 (2,991.6, 5,277.3) | <0.001* |
| IFN-γb | 25.8 (24.8, 27.3) | 28.0 (27.4, 30.8) | <0.001* |
| IL-1βb | 28.9 (28.7, 30.5) | 30.8 (30.0, 43.0) | <0.001* |
| IP-10b | 171.5 (167.6, 181.7) | 197.0 (173.1, 251.4) | <0.001* |
a
Data are for a total of 68 patients and are presented as medians (interquartile ranges) for continuous variables and numbers of individuals (percentages) for categorical variables. AFB, acid-fast bacillus; NA, not applicable; *, significant difference between the two groups (P < 0.05).
b
P values were calculated by the Mann-Whitney U test for continuous variables.
c
P values were calculated by the chi-square test for categorical variables.
d
P values were calculated by Fisher's exact test for categorical variables.