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. 2009 Dec 9;17(2):223–231. doi: 10.1128/CVI.00381-09

TABLE 2.

Characteristics and cytokine expression of TB patients stratified by treatment outcome at 2 monthsa

Characteristic Late responders (n = 12) Early responders (n = 20) P
Age (yr)b 63.5 (43.8, 79.5) 50 (39.3, 74.3) 0.255
Genderd 0.581
    Male 10 (83.3) 18 (90.0)
    Female 2 (16.7) 2 (10.0)
Smokingd 0.381
    Never 8 (66.7) 16 (80.0)
    Previous 1 (8.3) 0 (0.0)
    Current 3 (25.0) 4 (20.0)
Severity of lung diseasec 0.854
    Limited 5 (41.7) 9 (45.0)
    Extended 7 (58.3) 11 (55.0)
Predominant lung patternc 0.149
    Coalescent 6 (50.0) 15 (75.0)
    Disseminated 6 (50.0) 5 (25.0)
AFB smear result before therapyc 0.102
    Negative 10 (83.3) 11 (55.0)
    Positive 2 (16.7) 9 (45.0)
AFB smear result after 2 mo 0.114
    Negative 7 (58.3) 14 (70.0)
    Positive 5 (41.7) 6 (30.0)
Sputum TB culture result after 2 mo <0.001*
    Negative 0 (0.0) 14 (70.0)
    Positive 12 (100.0) 6 (30.0)
Cytokine concn (pg/ml) before anti-TB therapy
    TNF-αb 36.5 (33.1, 40) 34.5 (32.7, 37.8) 0.239
    IL-6b 10.6 (9.2, 12.5) 9.4 (9.3, 10.5) 0.659
    IL-8b 901.2 (762.8, 3,457.9) 892.1 (827, 2,267.4) 0.833
    IL-10b 29.3 (28.2, 32.4) 30.5 (29.8, 32.1) 0.346
    IL-12b 192.8 (189.3, 198.5) 192.9 (188.9, 198.4) 0.833
    MCP-1b 4,470.1 (3,102.9, 6,371.6) 3,206.6 (2,947.1, 5,134.3) 0.136
    IFN-γb 28.7 (27.2, 34.5) 28 (27.4, 30) 0.803
    IL-1βb 31.5 (29.8, 59.7) 30.7 (30.1, 35) 0.578
    IP-10b 236.8 (167.6, 333.5) 189.1 (175.5, 226.1) 0.387
Cytokine concn (pg/ml) 2 mo after anti-TB therapy
    TNF-αb 41.3 (36.4, 52.5) 30.2 (29.3, 32.6) <0.001*
    IL-6b 10.3 (9.3, 12.3) 9.4 (9.3, 10) 0.272
    IL-8b 925.4 (764.6, 1,617.7) 737.8 (721.7, 783.2) 0.005*
    IL-10b 30.4 (28.8, 33) 35.7 (32.2, 38.4) 0.004*
    IL-12b 193.5 (186.9, 201.2) 179.5 (179.1, 184.8) <0.001*
    MCP-1b 4,273.6 (2,979.5, 5,621.1) 2,922.3 (2,809.7, 3,024.4) 0.001*
    IFN-γb 28.6 (27.2, 33.1) 25.7 (25.4, 26.2) <0.001*
    IL-1βb 30.9 (30, 65.8) 29.6 (28.9, 29.9) <0.001*
    IP-10b 226.0 (167.5, 344.6) 169.8 (167.7, 180.5) 0.064
Cytokine concn (pg/ml) 5 mo after anti-TB therapy
    TNF-αb 33.1 (30.6, 34.4) 30.6 (29.9, 32.1) 0.032*
    IL-6b 9.7 (9.2, 10) 9.3 (9.3, 9.5) 0.632
    IL-8b 739.1 (726, 767.7) 730.2 (718.6, 756) 0.255
    IL-10b 29.8 (28.3, 31.8) 35.0 (32.8, 38.9) 0.007*
    IL-12b 189.6 (183.7, 194.7) 181.2 (179.7, 184.6) <0.001*
    MCP-1b 2,804.0 (2,775.6, 2,862.6) 2,791.5 (2,780.6, 2,847.1) 0.863
    IFN-γb 27.4 (25.8, 29.4) 25.8 (25.4, 26.5) 0.004*
    IL-1βb 30.1 (29, 30.5) 29.3 (28.9, 29.9) 0.070
    IP-10b 176.5 (167.4, 188.9) 170.0 (167.7, 174.6) 0.209
a

Data are for a total of 32 patients and are presented as medians (interquartile ranges) for continuous variables and numbers of individuals (percentages) for categorical variables. AFB, acid-fast bacillus; *, significant difference between the two groups (P < 0.05).

b

P values were calculated by the Mann-Whitney U test for continuous variables.

c

P values were calculated by the chi-square test for categorical variables.

d

P values were calculated by Fisher's exact test for categorical variables.