TABLE 3.

Kinetics of cytokine expression for 32 TB patients stratified by treatment outcome at 2 months^a

Cytokine concn (pg/ml) and time of measurement	Late responders (n = 12)	Early responders (n = 20)	P for late responders
TNF-α			0.076
Before	45.5 ± 24.8	40.2 ± 21.6
After 2 mo	57 ± 38.8	31 ± 2.7
After 6 mo	35.4 ± 7.9	31 ± 1.6
IL-6			0.442
Before	10.9 ± 1.7	12 ± 7.4
After 2 mo	11 ± 2	10.5 ± 3.1
After 6 mo	9.8 ± 0.8	9.6 ± 0.6
IL-8			0.914
Before	2,012.1 ± 2,124.5	2,323.8 ± 2,980.8
After 2 mo	1,574.4 ± 1,395.5	834.9 ± 339.8
After 6 mo	747.2 ± 28.6	736 ± 19.7
IL-10			0.821
Before	31.9 ± 6.1	33.2 ± 8.3
After 2 mo	31.4 ± 3.6	40 ± 15.7
After 6 mo	32 ± 5.6	39 ± 13.3
IL-12			0.136
Before	222.5 ± 99.7	208.9 ± 62.5
After 2 mo	210.3 ± 59.8	182.7 ± 7.2
After 6 mo	190.8 ± 8.5	183.2 ± 7.4
MCP-1			0.041*
Before	7,042.5 ± 6,901.2	3,921.6 ± 1,247.5
After 2 mo	5,431.9 ± 3,628.8	2,977.9 ± 239.9
After 6 mo	2,827.6 ± 69.4	2,822.4 ± 67
IFN-γ			0.061
Before	37 ± 23.1	30.5 ± 6.3
After 2 mo	33.9 ± 14.4	25.9 ± 0.9
After 6 mo	27.7 ± 1.9	26.0 ± 0.8
IL-1β			0.247
Before	96.5 ± 198.3	35.6 ± 10.6
After 2 mo	57.5 ± 52	29.5 ± 0.6
After 6 mo	32.6 ± 7.8	29.4 ± 0.6
IP-10			0.026*
Before	290 ± 175.3	205.1 ± 37.9
After 2 mo	255.4 ± 105.7	175.5 ± 12.5
After 6 mo	179.5 ± 13.7	171.7 ± 5.8

^aA linear mixed model with adjustment for age, gender, and sputum smear result was used. Data are presented as the means ± standard deviations. *, significant difference between the two groups (P < 0.05).