FIG. 7.
Intranasal immunization with rFopB-protected mice against pulmonary LVS challenge. C57BL/6 and HLA-DR4 tg mice (6/group) were i.n. or s.c. primed and boosted with rFopB. The mice were rested for 16 days after boosting, challenged i.n. with 35,000 CFU of LVS (∼5 LD50s), and monitored for survival. LVS-challenged mock-vaccinated mice were used as controls. The difference in the rate of survival between i.n. rFopB-immunized and mock-vaccinated mice was significant at a P value of <0.05 in both strains of mice.