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Immune response induced in HLA-DR4 tg mice by intranasal rFopB immunization. (A) Spleens were collected at 14 days postvaccination, and single cells were prepared and assayed for FopB- and LVS-induced IFN-γ production. Differences in IFN-γ stimulation between rFopB- and mock-vaccinated mice were significant at P values of <0.0001 for rFopB (**) and <0.01 for UV-LVS (*). (B) Sera were analyzed for their antibody profiles 14 days postboosting.
