Table 1.
Relationship between measures of breast density and eight continuous variables, by quartile
| Quartile 2 | Quartile 3 | Quartile 4 | ||||
|---|---|---|---|---|---|---|
| N | Ptrend | Phet | Coefficient (95% CI) |
Coefficient (95% CI) |
Coefficient (95% CI) |
|
| MRI % dense volume (log) | ||||||
| age | 655 | < 0.001 | < 0.001 | -0.02 (-0.14, 0.11) | -0.08 (-0.22, 0.06) | -0.38 (-0.52, -0.25) |
| weight | 519 | < 0.001 | < 0.001 | -0.29 (-0.42, -0.16) | -0.43 (-0.56, -0.29) | -0.83 (-0.97, -0.70) |
| BMI | 517 | < 0.001 | < 0.001 | -0.22 (-0.35, -0.09) | -0.48 (-0.61, -0.35) | -0.86 (-0.99, -0.72) |
| hip | 429 | < 0.001 | < 0.001 | -0.17 (-0.31, -0.03) | -0.29 (-0.45, -0.12) | -0.68 (-0.84, -0.53) |
| Waist | 438 | < 0.001 | < 0.001 | -0.10 (-0.25, 0.06) | -0.29 (-0.43, -0.14) | -0.65 (-0.81, -0.49) |
| Chest | 449 | < 0.001 | < 0.001 | -0.22 (-0.36, -0.09) | -0.37 (-0.52, -0.22) | -0.86 (-1.01, -0.70) |
| WHR | 427 | 0.006 | 0.032 | -0.09 (-0.26, 0.08) | -0.09 (-0.26, 0.08) | -0.26 (-0.43, -0.09) |
| Parity | 633 | 0.008 | 0.052 | -0.19 (-0.36, -0.01) | -0.19 (-0.33, -0.05) | -0.22 (-0.39, -0.05) |
| Cumulus % dense area | ||||||
| age | 607 | 0.003 | 0.004 | -1.58 (-5.87, 2.71) | -0.53 (-5.20, 4.14) | -7.66 (-12.2, -3.08) |
| weight | 464 | < 0.001 | < 0.001 | -9.21 (-13.7, -4.72) | -17.2 (-21.7, -12.7) | -26.6 (-31.0, -22.1) |
| BMI | 462 | < 0.001 | < 0.001 | -7.97 (-12.4, -3.56) | -15.7 (-20.1, -11.3) | -27.6 (-32.0, -23.3) |
| hip | 378 | < 0.001 | < 0.001 | -5.59 (-10.4, -0.78) | -10.7 (-16.3, -5.10) | -24.4 (-29.3, -19.6) |
| Waist | 386 | < 0.001 | < 0.001 | -3.56 (-8.99, 1.86) | -11.3 (-16.2, -6.47) | -20.9 (-26.0, -15.8) |
| Chest | 397 | < 0.001 | < 0.001 | -9.73 (-14.2, -5.28) | -13.9 (-18.9, -8.89) | -29.6 (-34.7, -24.6) |
| WHR | 375 | 0.003 | 0.005 | -6.14 (-11.8, -0.49) | -3.18 (-8.95, 2.59) | -10.1 (-15.9, -4.41) |
| Parity | 596 | < 0.001 | 0.002 | -5.70 (-11.2, -0.20) | -5.82 (-10.4, -1.26) | -8.70 (-14.1, -3.27) |
| Visually Assessed % dense area | ||||||
| age | 599 | 0.001 | 0.004 | -1.69 (-6.13, 2.75) | -1.71 (-6.52, 3.10) | -8.34 (-13.1, -3.60) |
| weight | 458 | < 0.001 | < 0.001 | -6.87 (-11.7, -2.05) | -14.1 (-18.9, -9.29) | -24.8 (-29.5, -20.0) |
| BMI | 456 | < 0.001 | < 0.001 | -6.22 (-11.0, -1.46) | -12.5 (-17.2, -7.70) | -26.0 (-30.6, -21.3) |
| hip | 374 | < 0.001 | < 0.001 | -4.29 (-9.33, 0.76) | -8.80 (-14.7, -2.94) | -23.6 (-28.6, -18.5) |
| Waist | 382 | < 0.001 | < 0.001 | -3.21 (-8.91, 2.49) | -9.63 (-14.7, -4.53) | -21.1 (-26.4, -15.7) |
| Chest | 391 | < 0.001 | < 0.001 | -9.64 (-14.3, -4.93) | -13.3 (-18.6, -8.00) | -29.5 (-34.8, -24.2) |
| WHR | 371 | 0.007 | 0.01 | -5.51 (-11.4, 0.36) | -2.31 (-8.32, 3.71) | -9.81 (-15.8, -3.83) |
| Parity | 588 | < 0.001 | < 0.001 | -5.66 (-11.3, -0.05) | -6.41 (-11.1, -1.75) | -10.8 (-16.4, -5.31) |
| Quartile 2 | Quartile 3 | Quartile 4 | ||||
| N | Ptrend | Phet |
Coefficient (95% CI) |
Coefficient (95% CI) |
Coefficient (95% CI) |
|
| MRI dense volume (×103, log) | ||||||
| age | 651 | 0.24 | 0.57 | -0.05 (-0.18, 0.08) | -0.03 (-0.17, 0.12) | -0.10 (-0.25, 0.04) |
| weight | 515 | 0.12 | 0.38 | 0.07 (-0.09, 0.23) | 0.13 (-0.03, 0.29) | 0.11 (-0.05, 0.28) |
| BMI | 513 | 0.75 | 0.47 | 0.10 (-0.05, 0.26) | 0.10 (-0.06, 0.26) | 0.02 (-0.14, 0.19) |
| hip | 425 | 0.072 | 0.13 | 0.12 (-0.04, 0.29) | 0.21 (0.02, 0.40) | 0.13 (-0.04, 0.31) |
| Waist | 434 | 0.063 | 0.19 | -0.03 (-0.21, 0.15) | 0.12 (-0.04, 0.28) | 0.13 (-0.05, 0.31) |
| Chest | 445 | 0.021 | 0.034 | 0.07 (-0.09, 0.22) | 0.25 (0.08, 0.42) | 0.15 (-0.04, 0.33) |
| WHR | 423 | 0.25 | 0.64 | 0.00 (-0.18, 0.18) | 0.08 (-0.10, 0.26) | 0.09 (-0.10, 0.27) |
| Parity | 629 | 0.14 | 0.46 | -0.13 (-0.31, 0.05) | -0.10 (-0.25, 0.04) | -0.11 (-0.29, 0.06) |
| Cumulus dense volume (×103) | ||||||
| age | 607 | 0.35 | 0.21 | -187 (-433, 59.0) | 15.1 (-252, 283) | -201 (-464, 61.9) |
| weight | 464 | 0.003 | 0.017 | 9.71 (-267, 286) | -233 (-509, 43.4) | -366 (-641, -92.1) |
| BMI | 462 | 0.001 | 0.004 | 52.7 (-223, 328) | -150 (-426, 127) | -419 (-690, -148) |
| hip | 378 | < 0.001 | < 0.001 | 95.6 (-181, 372) | 47.4 (-274, 369) | -545 (-824, -266) |
| Waist | 386 | 0.027 | 0.14 | -12.2 (-322, 298) | -135 (-414, 143) | -323 (-613, -31.9) |
| Chest | 397 | 0.003 | < 0.001 | 77.1 (-187, 341) | 79.5 (-219, 378) | -516 (-817, -216) |
| WHR | 375 | 0.99 | 0.55 | -83.7 (-387, 219) | 122 (-187, 432) | -67.6 (-375, 240) |
| Parity | 596 | 0.001 | 0.012 | -287 (-601, 26.6) | -285 (-545, -25.1) | -447 (-756, -137) |
N = number of women for whom data were available. Ptrend and Phet are P-values for the tests of trend (1 df) and heterogeneity (3 df) respectively between quartiles. Coefficients are for each quartile of the variable relative to the lowest quartile.