TABLE 1.
Clinical characteristics of 90 cases of invasive S. pyogenes disease in New Caledonia
| Characteristic | No. of cases by major ethnocultural group |
P valueb | OR | 95% CI | No. of cases by age group |
P valueb | OR | 95% CI | No. of cases by sex |
P valueb | OR | 95% CI | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indigenous Melanesian (n = 66) | Nonindigenous European/ Polynesian/ other (n = 25) | ≤30 yr (n = 54) | >30 yr (n = 37) | Male (n = 61) | Female (n = 30) | ||||||||||
| Predominant clinical manifestations | |||||||||||||||
| NF | 24 | 17 | ≤0.01 | 0.3 | 0.1-0.9 | 29 | 12 | ≤0.05 | NS | NS | 31 | 10 | NS | ||
| Bacteremia | 9 | 3 | NS | 5 | 7 | NS | 6 | 6 | NS | ||||||
| Myositis | 9 | 1 | NS | 6 | 4 | NS | 7 | 3 | NS | ||||||
| Arthritis | 6 | 3 | NS | 4 | 5 | NS | 8 | 1 | NS | ||||||
| Erysipelas | 6 | 2 | NS | 1 | 7 | ≤0.01 | 0.1 | 0.1-0.7 | 4 | 4 | NS | ||||
| Pneumonia | 2 | 0 | NS | 0 | 2 | NS | 2 | 0 | NS | ||||||
| At least one comorbidity, except skin lesiona | 33 | 19 | ≤0.03 | 0.3 | 0.1-0.9 | 21 | 31 | ≤0.01 | 0.1 | 0.1-0.4 | 32 | 20 | NS | ||
| Skin lesion | 46 | 18 | NS | 37 | 27 | NS | 48 | 16 | ≤0.01 | 3.2 | 1.1-9.2 | ||||
| Molecular marker emm15 | 13 | 1 | ≤0.06 | NS | NS | 9 | 5 | NS | 7 | 7 | NS | ||||
a
Comorbidities studied: obesity, ethanol abuse, recent delivery, immunosuppression, dialysis, use of NSAIDs, cardiopulmonary disease, diabetes mellitus, recent (<7 days before) surgery, intravenous drug use, corticotherapy for >6 months, and malignancy treatment.
b
NS, not significant; significant, P > 0.05. The chi-square or Student t test was used, depending on the number of samples.