TABLE 1.
Comparative antibiotic susceptibility patterns of Nocardia brasiliensis and Nocardia pseudobrasiliensis, including the case reported here and others from the literaturee
| Drug | MIC breakpoint(s)a | Results for N. pseudobrasiliensis isolate(s) from: |
Result for N. brasiliensis isolates from reference 4d | |||
|---|---|---|---|---|---|---|
| This case report |
Reference |
|||||
| MIC (interpretation) | Inhibition zoneb (interpretation) | 25 (% with susceptibility)c | 15d | |||
| Amikacin | ≤8, ≥16 | ND | 24 (S) | S (100) | S | S |
| Amoxicillin-clavulanic acid | ≤8/4, ≥32/16 | 2 (S) | 12 (R) | R (81) | ND | S |
| Ceftriaxone | ≤8, ≥64 | ND | 20 (S) | S (69) | R | S |
| Ciprofloxacin | ≤1, ≥4 | 0.125 (S) | 33 (S) | S (95) | S | R |
| Clarithromycin | ≤2, ≥8 | 0.125 (S) | ND | S (91) | S | R |
| Imipenem | ≤4, ≥16 | >32 (R) | 8 (R) | R (>90) | R | S |
| Linezolid | ≤8 | ND | 35 (S) | ND | S | S |
| Minocycline | ≤1, ≥8 | ND | 27 (S) | ND | R | S |
| Sulfamethoxazole | ≤32, ≥64 | ND | 6 (S) | S (94) | R | S |
| Tobramycin | ≤4, ≥16 | ND | 32 (S) | ND | ND | ND |
a
MIC resistance breakpoints are those from the NCCLS (16): the first value indicates the susceptibility breakpoint, and the second value indicates the resistance breakpoint.
b
Inhibition zones, measured in millimeters, were determined by the Mueller-Hinton agar disk diffusion method.
c
The percentage of susceptible or resistant strains as determined by the Etest method.
d
MICs were determined by the Etest method.