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. 2009 Dec 16;48(2):619–622. doi: 10.1128/JCM.02338-09

FIG. 1.

FIG. 1.

Phylogenetic dendrogram constructed by using the maximum-likelihood method implemented in the PHYLO_WIN program, version 2.0 (4), based on the alignment of the complete VP1 gene sequences of 66 CVA16 strains (from HFMD patients in the Shandong, Gansu, Inner Mongolia, Qinghai, Beijing, and Guangdong provinces of China) and 1 CVA16 prototype strain (G-10). The bootstrap values from 1,000 pseudoreplicates for major lineages within the tree are shown as percentages. Twelve Chinese CVA16 strains, which were isolated from 12 HFMD cases during 2007-2008 and are indicated by filled circles (•), and 9 strains, which were isolated from 9 HFMD cases in two provinces during 1999-2005 and are indicated by a triangle (▴), were selected for further molecular epidemiological analysis. Abbreviations of provinces of China: GS, Gansu; NM, Inner Mongolia; SD, Shandong; QH, Qinghai; BJ, Beijing; GD, Guangdong.