TABLE 1.

Estimation of the nucleotide substitution rate in the VP1 capsid region of CVA16

Data set	Substitution rate (substitutions per nucleotide per yr)a
	Ks	R2	Kt	R2
Cluster B1ab	1.25 × 10−2	0.756	3.75 × 10−3	0.600
Subgenotype B2c	1.19 × 10−2	0.973	3.41 × 10−3	0.976
Avgd	0.91 × 10−2		2.49 × 10−3

^aK_s, synonymous substitutions; Kt, total substitutions; R², linear regression coefficient.

^bTwenty-six strains, 1997-2008.

^cNine strains, 1981-2000.

^dAverage for cluster B1a and subgenotype B2.