TABLE 1.
Cytology and histology by varying HC2 positivity thresholdsa
| Parameter and group | Total no. | No. (%) of HC2 results |
|||
|---|---|---|---|---|---|
| <1 RLU | 1 to <2 RLU | 2 to <4 RLU | ≥4 RLU | ||
| Cytology | |||||
| Normal | 16,042 | 14,367 (89.6) | 389 (2.4) | 249 (1.6) | 1,037 (6.5) |
| Borderline/mild | 1,986 | 1,119 (56.3) | 65 (3.3) | 34 (1.7) | 768 (38.7) |
| Moderate/worse | 358 | 40 (11.2) | 3 (0.8) | 4 (1.1) | 311 (86.9) |
| All women | 18,386 | 15,526 (84.4) | 457 (2.5) | 287 (1.6) | 2,116 (11.5) |
| Histology by cytology in round 1 | |||||
| Normal (n = 16,042) | |||||
| CIN2 | 22 | 4 (18.2) | 0 (0) | 18 (81.8) | |
| CIN3+ | 10 | 1 (10) | 2 (20) | 7 (70) | |
| Borderline/mild (n = 1,986) | |||||
| CIN2 | 100 | 18 (18) | 4 (4) | 3 (3) | 75 (75) |
| CIN3+ | 71 | 3 (4.2) | 2 (2.8) | 0 (0) | 66 (93) |
| Moderate/worse (n = 358) | |||||
| CIN2 | 98 | 5 (5.1) | 2 (2.0) | 1 (1.0) | 90 (91.8) |
| CIN3+ | 152 | 4 (2.6) | 1 (0.7) | 2 (1.3) | 145 (95.4) |
| All cytology grades (n = 18,386) | |||||
| CIN2 in round 1 | 220 | 23 (10.5) | 10 (4.5) | 4 (1.8) | 183 (83.2) |
| CIN3+ in round 1 | 233 | 7 (3.0) | 4 (1.7) | 4 (1.7) | 218 (93.6) |
a
Revealed arm only (n = 18,386).