Table 1.

Treatment Plan (N = 38)

Cohort	No.	Drug and Dose
All		Fludarabine 25 mg/m2 days 1-5
		Rituximab 375 mg/m2 day 1
		Every 28 days for up to 6 cycles
1	15	Flavopiridol 50 mg/m2 day 1
2	6	Flavopiridol 50 mg/m2 days 1 to 2
3	3	Flavopiridol 20 mg/m2 30-minute intravenous + 20 mg/m2 4-hour intravenous day 1*
4	14	Flavopiridol 30 mg/m2 30-minute intravenous + 30 mg/m2 4-hour intravenous day 1*

^*Flavopiridol was given by 30-minute intravenous bolus followed by 4-hour intravenous infusion starting in cycle 2.