Table 4.
Mean Pharmacokinetics of VEGF Bound to VEGF Trap After Intravenous Administration of Aflibercept, Expressed As Equivalent Free VEGF Trap
| Dose Level(mg/kg) | Pharmacokinetic Parameter |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Tmax (day) |
Cmax (μg/mL) |
Tlast (day) |
Clast (μg/mL) |
AUClast (day × μg/mL) |
||||||
| Median | Range | Coefficient of Variation | % | Median | Range | Coefficient of Variation | % | Coefficient of Variation | % | |
| 0.3 (n = 3) | 9.96 | 7.03-9.98 | 0.575 | 5 | 13.9 | 13.8-14 | 0.494 | 16 | 5.53 | 5 |
| 1.0 (n = 7) | 9.98 | 7-14 | 1.22 | 29 | 14 | 9.86-14 | 1.12 | 38 | 9.98 | 30 |
| 2.0 (n = 6) | 13.5 | 9.01-13.9 | 1.58 | 32 | 13.9 | 9.01-13.9 | 1.57 | 32 | 12.7 | 41 |
| 3.0 (n = 7) | 13.9 | 7.08-23 | 1.72 | 23 | 14 | 13.9-23 | 1.55 | 34 | 16.1 | 38 |
| 4.0 (n = 7) | 9.99 | 3.04-14 | 1.34 | 45 | 10 | 3.04-14 | 1.27 | 49 | 10.8 | 38 |
| 5.0 (n = 4) | 10.5 | 6.98-21.8 | 1.94 | 25 | 11.9 | 7.04-21.8 | 1.94 | 25 | 12.9 | 18 |
| 7.0 (n = 13) | 14 | 7.02-27.9 | 2.37 | 37 | 14 | 7.03-27.9 | 2.35 | 38 | 20.9 | 26 |
Abbreviations: VEGF, vascular endothelial growth factor; Tmax, time of maximum plasma concentration; Cmax, maximum observed plasma concentration; Tlast, time of last measurable plasma concentration; Clast, last measurable (non-zero) plasma concentration; AUClast, area under the curve from the time of dosing to the last measurable concentration.